Home SOUTH AMERICA 2 Weeks in South America: Where to Go and What to Explore

2 Weeks in South America: Where to Go and What to Explore

by Holly

South America, a continent of diverse cultures, stunning landscapes, and rich history, offers an incredible array of experiences for travelers. With its vibrant cities, lush rainforests, towering mountains, and pristine beaches, planning a two-week itinerary can be both exciting and challenging. In this article, we will guide you through an unforgettable journey across South America, highlighting the must-visit destinations and the activities that make this continent a traveler’s dream.

Exploring the Dynamic Duo: Rio de Janeiro and São Paulo

1. Rio de Janeiro

Begin your South American adventure in the iconic city of Rio de Janeiro, Brazil. Famous for its lively atmosphere, white-sand beaches, and the towering Christ the Redeemer statue, Rio offers an electrifying blend of culture and nature. Stroll along the vibrant Copacabana and Ipanema beaches, explore the bohemian neighborhood of Santa Teresa, and ascend Corcovado Mountain for panoramic views of the city.

2. São Paulo

A short flight away lies São Paulo, Brazil’s bustling metropolis. Immerse yourself in its cultural diversity by visiting the São Paulo Museum of Art, exploring the trendy Vila Madalena district, and savoring the city’s renowned culinary scene. Don’t miss the opportunity to witness the city’s vibrant street art culture as you wander through its dynamic neighborhoods.

Nature’s Majesty: The Amazon Rainforest


From São Paulo, fly to Manaus, gateway to the Amazon Rainforest. Embark on a once-in-a-lifetime adventure as you explore the world’s largest tropical rainforest. Cruise down the Amazon River, encounter unique wildlife, and learn about indigenous cultures that have thrived in this ecosystem for centuries. A visit to the Meeting of Waters, where the dark Rio Negro meets the lighter-colored Amazon River, is a mesmerizing natural phenomenon.

Andean Wonders: Cusco and Machu Picchu

1. Cusco

Fly from Manaus to Cusco, Peru, a city steeped in history and culture. As the former capital of the Inca Empire, Cusco boasts impressive architecture, including the famous Qorikancha temple and the Sacsayhuamán fortress. Acclimate to the high altitude while exploring the city’s cobblestone streets, vibrant markets, and local eateries.

2. Machu Picchu

A short train ride from Cusco takes you to the awe-inspiring Machu Picchu. This ancient Incan city perched high in the Andes offers an unforgettable experience. Witness the sunrise over the ruins, explore the intricate stone architecture, and hike to the Sun Gate for panoramic views of the citadel and surrounding mountains.

A Tango in Buenos Aires

Buenos Aires

From Peru, head to the vibrant capital of Argentina, Buenos Aires. Known for its passionate tango music and dance, Buenos Aires is a city that exudes elegance and flair. Explore the historic neighborhoods of San Telmo and La Boca, visit the iconic Recoleta Cemetery, and indulge in Argentina’s world-renowned steak and wine.

Chilean Splendors: Santiago and Valparaíso

1. Santiago

Fly to Santiago, Chile’s modern and cosmopolitan capital. Surrounded by the Andes, Santiago offers a mix of contemporary architecture and historic sites. Take a cable car to the top of San Cristóbal Hill for panoramic city views, visit the historic Plaza de Armas, and explore the bohemian Bellavista district.

2. Valparaíso

A short trip from Santiago brings you to the colorful and artistic city of Valparaíso. With its hillside neighborhoods, vibrant street art, and picturesque harbor, Valparaíso is a UNESCO World Heritage site that captivates visitors with its charm. Explore the labyrinthine streets and ride the historic funiculars for stunning views of the city and the Pacific Ocean.

Sunset on the Beaches of Cartagena


Conclude your South American journey in the enchanting city of Cartagena, Colombia. This coastal gem boasts beautifully preserved colonial architecture and a rich history. Wander through the walled Old Town, visit the San Felipe de Barajas Castle, and unwind on the white-sand beaches along the Caribbean Sea. The vibrant colors, warm breezes, and captivating sunsets make Cartagena a perfect finale to your adventure.


Two weeks in South America can take you on a whirlwind tour through some of the continent’s most incredible destinations. From the vibrant cities of Brazil to the natural wonders of the Amazon Rainforest, the ancient ruins of Machu Picchu, and the charming streets of Buenos Aires and Valparaíso, this itinerary offers a diverse range of experiences that cater to every traveler’s interests. Each destination tells a unique story, weaving together history, culture, and nature into an unforgettable tapestry that will leave you with cherished memories for a lifetime. So, pack your bags, prepare your camera, and get ready to embark on a journey that will undoubtedly leave you in awe of South America’s boundless beauty and endless possibilities.

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